Stumped by the crossword clue "Toxic substance"? You're not alone — this clue appeared in the LA Times Daily Crossword puzzle on October 2, 2018. We've scoured our database and found 87 possible solutions. The strongest candidate is POISON (6 letters) at 99% confidence, based on data from published crossword puzzles.
Answer For Toxic substance:
Tap each ? to reveal a letter, or show all at once.
87 Other Potential Answers
Rank
Answer
Length
Source
Date
99%
POISON
Toxic substance
(6)
LA Times Daily Crossword
Oct 2, 2018
99%
POISON
Toxic substance
LA Times Daily Crossword · Oct 2, 2018
8%
MEAL
Ground substance
(4)
LA Times Daily Crossword
Sep 12, 2026
8%
MEAL
Ground substance
LA Times Daily Crossword · Sep 12, 2026
8%
ALKALI
High-pH substance
(6)
LA Times Daily Crossword
Jul 1, 2026
8%
ALKALI
High-pH substance
LA Times Daily Crossword · Jul 1, 2026
8%
CAULK
Sealing substance
(5)
LA Times Daily Crossword
Feb 20, 2026
8%
CAULK
Sealing substance
LA Times Daily Crossword · Feb 20, 2026
8%
FLESH
___ out (give substance to)
(5)
Universal Crossword
Feb 10, 2026
8%
FLESH
___ out (give substance to)
Universal Crossword · Feb 10, 2026
8%
GOO
Slimy substance
(3)
Universal Crossword
Jan 1, 2026
8%
GOO
Slimy substance
Universal Crossword · Jan 1, 2026
8%
ACID
Low-pH substance
(4)
Universal Crossword
Nov 22, 2025
8%
ACID
Low-pH substance
Universal Crossword · Nov 22, 2025
8%
OLEIC
___ acid (soapmaker's substance)
(5)
Universal Crossword
Aug 15, 2025
8%
OLEIC
___ acid (soapmaker's substance)
Universal Crossword · Aug 15, 2025
8%
BASE
High-pH substance
(4)
LA Times Daily Crossword
Aug 4, 2025
8%
BASE
High-pH substance
LA Times Daily Crossword · Aug 4, 2025
8%
TAR
Paving substance
(3)
Universal Crossword
Jul 27, 2025
8%
TAR
Paving substance
Universal Crossword · Jul 27, 2025
8%
GEL
Hairstyling substance
(3)
Universal Crossword
Jul 16, 2025
8%
GEL
Hairstyling substance
Universal Crossword · Jul 16, 2025
8%
SOAP
Cleaning substance
(4)
Universal Crossword
Jun 5, 2025
8%
SOAP
Cleaning substance
Universal Crossword · Jun 5, 2025
8%
GOOP
Sticky substance
(4)
Universal Crossword
May 4, 2025
8%
GOOP
Sticky substance
Universal Crossword · May 4, 2025
8%
NOTHINGBURGER
Something lacking substance, in slang
(13)
Universal Crossword
Mar 22, 2025
8%
NOTHINGBURGER
Something lacking substance, in slang
Universal Crossword · Mar 22, 2025
8%
FONDANT
Cake decorator's substance
(7)
LA Times Daily Crossword
Nov 21, 2024
8%
FONDANT
Cake decorator's substance
LA Times Daily Crossword · Nov 21, 2024
8%
EXIST
Have substance
(5)
Thomas Joseph Crossword
Sep 5, 2024
8%
EXIST
Have substance
Thomas Joseph Crossword · Sep 5, 2024
8%
ALOE
Plant toxic to some pets
(4)
LA Times Daily Crossword
Aug 8, 2024
8%
ALOE
Plant toxic to some pets
LA Times Daily Crossword · Aug 8, 2024
8%
DARK
With 60-Across, hypothetical substance in outer space ... and a literal hint to six black squares in this puzzle
(4)
Universal Crossword
Aug 8, 2024
8%
DARK
With 60-Across, hypothetical substance in outer space ... and a literal hint to six black squares in this puzzle
Universal Crossword · Aug 8, 2024
8%
MEATY
Full of substance
(5)
Universal Crossword
Aug 3, 2024
8%
MEATY
Full of substance
Universal Crossword · Aug 3, 2024
8%
SOOT
Chimney substance
(4)
Universal Crossword
Jan 28, 2024
8%
SOOT
Chimney substance
Universal Crossword · Jan 28, 2024
8%
TREESAP
Syrupy substance
(7)
Universal Crossword
Jan 15, 2024
8%
TREESAP
Syrupy substance
Universal Crossword · Jan 15, 2024
8%
AQUA
__ regia: gold-dissolving substance
(4)
LA Times Daily Crossword
Dec 23, 2023
8%
AQUA
__ regia: gold-dissolving substance
LA Times Daily Crossword · Dec 23, 2023
8%
LSD
Trip-inducing substance
(3)
Universal Crossword
Nov 24, 2023
8%
LSD
Trip-inducing substance
Universal Crossword · Nov 24, 2023
8%
SILICA
Sand substance
(6)
Thomas Joseph Crossword
Nov 7, 2023
8%
SILICA
Sand substance
Thomas Joseph Crossword · Nov 7, 2023
8%
HOLLOW
Lacking substance
(6)
LA Times Daily Crossword
Oct 26, 2023
8%
HOLLOW
Lacking substance
LA Times Daily Crossword · Oct 26, 2023
8%
SLOWLORIS
Large-eyed primate with a toxic bite
(9)
LA Times Daily Crossword
Sep 23, 2023
8%
SLOWLORIS
Large-eyed primate with a toxic bite
LA Times Daily Crossword · Sep 23, 2023
8%
STEROID
Doping substance
(7)
Premier Sunday Crossword
Sep 17, 2023
8%
STEROID
Doping substance
Premier Sunday Crossword · Sep 17, 2023
8%
TULIP
Edible flower whose bulb has a toxic core
(5)
LA Times Daily Crossword
Sep 1, 2023
8%
TULIP
Edible flower whose bulb has a toxic core
LA Times Daily Crossword · Sep 1, 2023
8%
COALFIRE
Underground blaze that emits toxic gases
(8)
LA Times Daily Crossword
Jul 29, 2023
8%
COALFIRE
Underground blaze that emits toxic gases
LA Times Daily Crossword · Jul 29, 2023
8%
SUMAC
Shrub that may be toxic
(5)
LA Times Daily Crossword
Mar 8, 2023
8%
SUMAC
Shrub that may be toxic
LA Times Daily Crossword · Mar 8, 2023
8%
MALEEGO
One source of toxic behavior
(7)
LA Times Daily Crossword
Feb 18, 2023
8%
MALEEGO
One source of toxic behavior
LA Times Daily Crossword · Feb 18, 2023
8%
DRUG
Controlled substance
(4)
Universal Crossword
Dec 17, 2022
8%
DRUG
Controlled substance
Universal Crossword · Dec 17, 2022
8%
POSER
Someone who's all style and no substance
(5)
LA Times Daily Crossword
Oct 1, 2022
8%
POSER
Someone who's all style and no substance
LA Times Daily Crossword · Oct 1, 2022
8%
LYE
Soapmaking substance
(3)
Universal Crossword
Sep 18, 2022
8%
LYE
Soapmaking substance
Universal Crossword · Sep 18, 2022
8%
INK
Blot substance
(3)
Universal Crossword
Jun 22, 2022
8%
INK
Blot substance
Universal Crossword · Jun 22, 2022
8%
HOTWAX
Hair removal substance
(6)
LA Times Daily Crossword
May 23, 2022
8%
HOTWAX
Hair removal substance
LA Times Daily Crossword · May 23, 2022
8%
CLAY
Pottery substance
(4)
Universal Crossword
Apr 11, 2022
8%
CLAY
Pottery substance
Universal Crossword · Apr 11, 2022
8%
POISONOUSS
Reptile that's toxic to eat, pictorially?
(10)
Universal Crossword
Feb 1, 2022
8%
POISONOUSS
Reptile that's toxic to eat, pictorially?
Universal Crossword · Feb 1, 2022
8%
GLUE
"Krazy" substance
(4)
Universal Crossword
Jan 21, 2022
8%
GLUE
"Krazy" substance
Universal Crossword · Jan 21, 2022
8%
VENOM
Scorpion's substance
(5)
Universal Crossword
Jan 14, 2022
8%
VENOM
Scorpion's substance
Universal Crossword · Jan 14, 2022
8%
CORAL
Reef substance
(5)
Universal Crossword
Nov 12, 2021
8%
CORAL
Reef substance
Universal Crossword · Nov 12, 2021
8%
SADD
Org. concerned with youth substance abuse
(4)
LA Times Daily Crossword
Aug 29, 2021
8%
SADD
Org. concerned with youth substance abuse
LA Times Daily Crossword · Aug 29, 2021
8%
THIN
Lacking substance
(4)
Universal Crossword
May 20, 2021
8%
THIN
Lacking substance
Universal Crossword · May 20, 2021
8%
SAP
Tree substance
(3)
Universal Crossword
May 4, 2021
8%
SAP
Tree substance
Universal Crossword · May 4, 2021
8%
DYE
Hair-coloring substance
(3)
Universal Crossword
Feb 1, 2021
8%
DYE
Hair-coloring substance
Universal Crossword · Feb 1, 2021
8%
TOXIN
Deadly substance
(5)
Thomas Joseph Crossword
Feb 1, 2021
8%
TOXIN
Deadly substance
Thomas Joseph Crossword · Feb 1, 2021
8%
EAU
Seine substance
(3)
Universal Crossword
Jan 21, 2021
8%
EAU
Seine substance
Universal Crossword · Jan 21, 2021
8%
REAGENT
Chem lab substance
(7)
LA Times Daily Crossword
Oct 31, 2020
8%
REAGENT
Chem lab substance
LA Times Daily Crossword · Oct 31, 2020
8%
VAPID
Lacking intellectual substance
(5)
Universal Crossword
Aug 24, 2020
8%
VAPID
Lacking intellectual substance
Universal Crossword · Aug 24, 2020
8%
YLEM
Primordial substance, in physics
(4)
LA Times Daily Crossword
Aug 23, 2020
8%
YLEM
Primordial substance, in physics
LA Times Daily Crossword · Aug 23, 2020
8%
PLASMA
Commonly donated substance
(6)
Universal Crossword
Aug 20, 2020
8%
PLASMA
Commonly donated substance
Universal Crossword · Aug 20, 2020
8%
TALCUM
Friction-reducing substance
(6)
LA Times Daily Crossword
Jun 4, 2020
8%
TALCUM
Friction-reducing substance
LA Times Daily Crossword · Jun 4, 2020
8%
RESIN
Sticky pine substance
(5)
Universal Crossword
Nov 27, 2019
8%
RESIN
Sticky pine substance
Universal Crossword · Nov 27, 2019
8%
ROID
Doping scandal substance, informally
(4)
Universal Crossword
Nov 22, 2019
8%
ROID
Doping scandal substance, informally
Universal Crossword · Nov 22, 2019
8%
NICOTINE
*Patch substance, sometimes
(8)
Universal Crossword
Nov 19, 2019
8%
NICOTINE
*Patch substance, sometimes
Universal Crossword · Nov 19, 2019
8%
RNA
Messenger substance
(3)
LA Times Daily Crossword
Mar 16, 2019
8%
RNA
Messenger substance
LA Times Daily Crossword · Mar 16, 2019
8%
OED
Ref. work whose 2018 Word of the Year is "toxic"
(3)
LA Times Daily Crossword
Jan 10, 2019
8%
OED
Ref. work whose 2018 Word of the Year is "toxic"
LA Times Daily Crossword · Jan 10, 2019
8%
PLASM
Suffix meaning "living substance"
(5)
LA Times Daily Crossword
Dec 9, 2018
8%
PLASM
Suffix meaning "living substance"
LA Times Daily Crossword · Dec 9, 2018
8%
TANNIN
Red wine substance
(6)
LA Times Daily Crossword
Aug 4, 2018
8%
TANNIN
Red wine substance
LA Times Daily Crossword · Aug 4, 2018
8%
OPIOID
Sedating substance
(6)
Premier Sunday Crossword
Jul 29, 2018
8%
OPIOID
Sedating substance
Premier Sunday Crossword · Jul 29, 2018
8%
AGER
Antiquing substance
(4)
Premier Sunday Crossword
Jul 15, 2018
8%
AGER
Antiquing substance
Premier Sunday Crossword · Jul 15, 2018
8%
NEOPRENE
Wetsuit substance
(8)
LA Times Daily Crossword
Jan 28, 2018
8%
NEOPRENE
Wetsuit substance
LA Times Daily Crossword · Jan 28, 2018
1%
GOOS
Honeylike substances
(4)
LA Times Daily Crossword
May 24, 2026
1%
GOOS
Honeylike substances
LA Times Daily Crossword · May 24, 2026
1%
TURNT
Intoxicated, informally
(5)
Universal Crossword
Mar 19, 2026
1%
TURNT
Intoxicated, informally
Universal Crossword · Mar 19, 2026
1%
DYES
Coloring substances
(4)
Universal Crossword
Jan 25, 2026
1%
DYES
Coloring substances
Universal Crossword · Jan 25, 2026
1%
LYES
Caustic substances
(4)
Universal Crossword
Nov 16, 2025
1%
LYES
Caustic substances
Universal Crossword · Nov 16, 2025
1%
OILS
"Natural" or "essential" substances
(4)
Universal Crossword
Aug 9, 2025
1%
OILS
"Natural" or "essential" substances
Universal Crossword · Aug 9, 2025
1%
HEADY
Intoxicating
(5)
LA Times Daily Crossword
Apr 17, 2025
1%
HEADY
Intoxicating
LA Times Daily Crossword · Apr 17, 2025
1%
ACIDS
Low-pH substances
(5)
Universal Crossword
Dec 15, 2024
1%
ACIDS
Low-pH substances
Universal Crossword · Dec 15, 2024
1%
STEWED
Intoxicated
(6)
Eugene Sheffer Crossword
Sep 20, 2024
1%
STEWED
Intoxicated
Eugene Sheffer Crossword · Sep 20, 2024
1%
PHEROMONES
Attractive substances
(10)
Universal Crossword
May 25, 2024
1%
PHEROMONES
Attractive substances
Universal Crossword · May 25, 2024
1%
KAVA
Intoxicating Polynesian drink
(4)
Universal Crossword
Feb 15, 2024
1%
KAVA
Intoxicating Polynesian drink
Universal Crossword · Feb 15, 2024
1%
CATNIP
Siamese intoxicant
(6)
Universal Crossword
Jan 10, 2024
1%
CATNIP
Siamese intoxicant
Universal Crossword · Jan 10, 2024
1%
HEADIER
More intoxicating
(7)
LA Times Daily Crossword
Dec 6, 2023
1%
HEADIER
More intoxicating
LA Times Daily Crossword · Dec 6, 2023
1%
MONADS
Elementary substances
(6)
Thomas Joseph Crossword
Sep 8, 2023
1%
MONADS
Elementary substances
Thomas Joseph Crossword · Sep 8, 2023
1%
GOOPS
Gummy substances
(5)
Eugene Sheffer Crossword
Nov 30, 2022
1%
GOOPS
Gummy substances
Eugene Sheffer Crossword · Nov 30, 2022
1%
SOLUTES
Chemistry lab substances
(7)
LA Times Daily Crossword
Oct 30, 2022
1%
SOLUTES
Chemistry lab substances
LA Times Daily Crossword · Oct 30, 2022
1%
RESINS
Sticky substances
(6)
Universal Crossword
May 20, 2022
1%
RESINS
Sticky substances
Universal Crossword · May 20, 2022
1%
INKBLOTTO
Intoxicated to the point at which getting a tattoo sounds like a good idea?
(9)
LA Times Daily Crossword
Mar 21, 2021
1%
INKBLOTTO
Intoxicated to the point at which getting a tattoo sounds like a good idea?
LA Times Daily Crossword · Mar 21, 2021
1%
POISONS
Deadly substances
(7)
Thomas Joseph Crossword
Feb 1, 2021
1%
POISONS
Deadly substances
Thomas Joseph Crossword · Feb 1, 2021
1%
DRIERS
Moisture-absorbing substances
(6)
LA Times Daily Crossword
Dec 4, 2020
1%
DRIERS
Moisture-absorbing substances
LA Times Daily Crossword · Dec 4, 2020
1%
BALMS
Soothing substances
(5)
Universal Crossword
Dec 12, 2019
1%
BALMS
Soothing substances
Universal Crossword · Dec 12, 2019
1%
SULFURIC
With 42-Across, corrosive substances
(8)
LA Times Daily Crossword
Sep 13, 2019
1%
SULFURIC
With 42-Across, corrosive substances
LA Times Daily Crossword · Sep 13, 2019
1%
BOOZY
Intoxicated
(5)
LA Times Daily Crossword
Apr 8, 2019
1%
BOOZY
Intoxicated
LA Times Daily Crossword · Apr 8, 2019
1%
DRUNKEN
Like an intoxicated spree
(7)
LA Times Daily Crossword
Oct 8, 2018
1%
DRUNKEN
Like an intoxicated spree
LA Times Daily Crossword · Oct 8, 2018
1%
ODORANTS
Scenting substances
(8)
Premier Sunday Crossword
Jul 29, 2018
1%
ODORANTS
Scenting substances
Premier Sunday Crossword · Jul 29, 2018
1%
COCAS
Intoxicating shrubs
(5)
LA Times Daily Crossword
May 2, 2018
1%
COCAS
Intoxicating shrubs
LA Times Daily Crossword · May 2, 2018
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Frequently Asked Questions
How many possible solutions does "Toxic substance" have?
We found 1 exact solution and 87 total potential answers including similar clues. The most likely answer is POISON (6 letters).
What is the best answer for "Toxic substance"?
The best answer for "Toxic substance" is POISON with 6 letters.
This answer has a 99% confidence rating based on our database of crossword solutions.
Where has "Toxic substance" been used as a crossword clue?
This clue has appeared 1 time in our database.
It has been featured in LA Times Daily Crossword.
It was last seen in the LA Times Daily Crossword on October 2, 2018.